Archive for July, 2010

Breast Cancer Incidence Plateaued

Women and clinicians are regularly reminded about the threat of breast cancer by the media, advertisements, and the experiences of friends or family members who are fighting the disease. And there is good reason for breast cancer to be prominent in our consciousness: The breast is the leading site of cancer in US women (32% […]

Impact of Androgens

Researchers who study the influence of hormones on behavior have the greatest difficulty in associating testosterone with any human behaviors whatsoever. They have injected all kinds of animals at all stages of development with synthetic testosterone to see how it affected their behavior. They have juggled the naturally occurring estrogens and androgens to see whether […]

Effect of Estrogen plus Progestin on Quality of Life

In the recently published analysis of the effects of estrogen plus progestin on health-related quality of life (QOL) in the Women’s Health Initiative (WHI), the authors concluded that this therapy did not have a clinically meaningful effect.1 However, caution is warranted in interpreting the findings of this analysis. The study design has several limitations that […]

Postmenopausal Hormone Therapy and Breast Cancer

Holmberg and Anderson recently published a research letter in the journal Lancet regarding early cessation of the HABITS study,1 a Scandinavian trial designed to evaluate the risk of breast cancer recurrence in women with previously treated breast cancers who were given hormone therapy (HT) for relief of menopausal symptoms. The primary objective of the study […]

Testosterone and Agression

Children, old people and women are all short of testosterone. Even ten years ago, testosterone was a word not often heard; nowadays the presence of testosterone in the environment is often remarked on. When the stands at the football ground are packed with vociferating fans it is described as a testosterone storm. When a driver […]

ERT for Menopausal Women With History of Breast Cancer

Women with a history of breast cancer have been advised to avoid estrogen replacement therapy (ERT). A reassessment of this approach has been initiated by several authors and clinical reports to date have not supported this tenet. The only prospective randomized trial reported to date is that of Vassilopoulou-Sellin et al. The authors conducted a […]

Testosterone: Use and Pharmaceutical Forms

The original intention of testosterone were the treatment of males who have too little or no natural endogenous testosterone production with hypogonadism. Appropriate use for this purpose is legitimate hormone replacement therapy which maintains serum testosterone levels in the normal range. Many other applications of testosterone includes the following: Infertility Lack of libido Erectile dysfunction […]