Archive for the 'menopause' Category

Effect of Estrogen plus Progestin on Quality of Life

In the recently published analysis of the effects of estrogen plus progestin on health-related quality of life (QOL) in the Women’s Health Initiative (WHI), the authors concluded that this therapy did not have a clinically meaningful effect.1 However, caution is warranted in interpreting the findings of this analysis. The study design has several limitations that […]

Postmenopausal Hormone Therapy and Breast Cancer

Holmberg and Anderson recently published a research letter in the journal Lancet regarding early cessation of the HABITS study,1 a Scandinavian trial designed to evaluate the risk of breast cancer recurrence in women with previously treated breast cancers who were given hormone therapy (HT) for relief of menopausal symptoms. The primary objective of the study […]

Hormones and Postmenopausal Health

Menopause-related estrogen loss is associated with symptoms that can have a negative impact on a woman’s sense of well-being and her daily activities. In addition, menopausal women are at an increased risk for developing osteoporosis. Therefore, for some menopausal women, hormone therapy (HT, administered as either unopposed estrogen or estrogen plus progestin) may be a […]