Impact of Androgens

Researchers who study the influence of hormones on behavior have the greatest difficulty in associating testosterone with any human behaviors whatsoever. They have injected all kinds of animals at all stages of development with synthetic testosterone to see how it affected their behavior. They have juggled the naturally occurring estrogens and androgens to see whether […]

Effect of Estrogen plus Progestin on Quality of Life

In the recently published analysis of the effects of estrogen plus progestin on health-related quality of life (QOL) in the Women’s Health Initiative (WHI), the authors concluded that this therapy did not have a clinically meaningful effect.1 However, caution is warranted in interpreting the findings of this analysis. The study design has several limitations that […]

ERT for Menopausal Women With History of Breast Cancer

Women with a history of breast cancer have been advised to avoid estrogen replacement therapy (ERT). A reassessment of this approach has been initiated by several authors and clinical reports to date have not supported this tenet. The only prospective randomized trial reported to date is that of Vassilopoulou-Sellin et al. The authors conducted a […]

Hormone Therapy and Osteoporosis

The effects of estrogen deficiency on the skeletal system have been clearly established for more than 60 years. The molecular mechanisms accounting for estrogen-related bone loss have been known for a decade or longer, and the benefits of estrogen on the skeleton have been recognized for half a century. The adverse consequences of estrogen depletion […]

Hormones and Postmenopausal Health

Menopause-related estrogen loss is associated with symptoms that can have a negative impact on a woman’s sense of well-being and her daily activities. In addition, menopausal women are at an increased risk for developing osteoporosis. Therefore, for some menopausal women, hormone therapy (HT, administered as either unopposed estrogen or estrogen plus progestin) may be a […]

Breast Cancer and Hormone Replacement Therapy

Recent findings from a large observational study conducted in Great Britain show that current use – but not past use- of postmenopausal therapy is associated with an increased risk of breast cancer as well as an increased incidence of breast cancer fatalities. This large cohort study1 confirms the findings from the Women’s Health Initiative (WHI) […]

About Testosterone Levels

Testosterone can be considered as an anti aging wonder drug (the decline of testosterone production with age has led to a demand for Androgen Replacement Therapy). It is often administered to female-to-male transsexual men as part of the hormone replacement therapy, with a “target level” of the normal male testosterone level. Likewise, male-to-female transsexual women […]

Natural vs. Synthetic Estrogenes

Our culture, which sees happiness as something you put in your mouth or inject into your body, no sooner suspected that estrogen, like serotonin, was a magic philter that would restore and maintain equilibrium, health and well-being, than it began clamoring for more and more of it. Synthetic versions were swiftly patented, manufactured and sold. […]

Hormones and Estrogen-Dependent Diseases

In an article in Brainwork J. Kinoshita speculated in the kind of way that inspires drug houses to finance the running of large-scale clinical trials, in this case of the effects of estrogen given in the post menopausal age on the incidence of Alzheimer’s disease. Elderly women are more prone than men to Alzheimer’s, but […]

Women and the Role of Estrogen

Estrogen seems to be as good for women as testosterone is bad for men. It makes women feel great and it doesn’t cost them anything. Adult females make it themselves out of cholesterol converted by their gonads and their adrenal cortex first into progesterone, then into testosterone and then into estrogen. The ovaries carry on […]